Tesofensine
An investigational weight loss tablet that affects three brain chemicals to suppress appetite and support metabolism.
Plain English
Patient-Friendly Explanation
Tesofensine is an investigational weight loss medication that works by increasing the levels of three brain chemicals — serotonin, dopamine, and noradrenaline — which together reduce appetite and may slightly boost metabolism. It is taken as a once-daily tablet.
Medical
Clinical Definition
Tesofensine is a triple monoamine reuptake inhibitor (serotonin-noradrenaline-dopamine) originally developed for Parkinson's and Alzheimer's disease but repurposed for obesity after weight loss was observed as a side effect. Phase II trials demonstrated dose-dependent weight loss of 4.5–10.6% over 24 weeks versus 2.0% for placebo, primarily through appetite suppression and increased satiety. Phase III trials are ongoing; it is not yet approved by major regulatory agencies.
Key Insight
Why It Matters
New medications are constantly being developed to address obesity from multiple biological angles. Dr Joseph Wang stays current with emerging weight management pharmacotherapy to offer patients the most appropriate and evidence-based treatment options available in Singapore.
Sources
Reviewed against standard medical references.
Medically reviewed by
Family Physician & Registered Acupuncturist, Accord Medical Clinic. MBBS (NUS), Graduate Diploma in Family Medicine (NUS), Graduate Diploma in Acupuncture (Singapore College of TCM).
Last reviewed: August 2026
This page is general health education, not medical advice. Whether any treatment is appropriate for you is a decision made in consultation after assessment.