Lipolysis
The biological process of breaking down stored fat into usable energy, driven by a caloric deficit and regulated by hormones.
Plain English
Patient-Friendly Explanation
Lipolysis is the process by which your body breaks down stored fat into smaller molecules that can be used for energy. It happens when you consume fewer calories than you burn, such as during fasting, exercise, or calorie restriction. This is the fundamental mechanism behind fat loss.
Medical
Clinical Definition
Lipolysis is the enzymatic hydrolysis of triglycerides stored in adipocytes into glycerol and free fatty acids, primarily catalysed by hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL). The process is regulated by catecholamines (stimulatory via β-adrenergic receptors) and insulin (inhibitory), with free fatty acids released into the circulation for β-oxidation in peripheral tissues.
Key Insight
Why It Matters
Understanding lipolysis helps patients appreciate why sustainable weight loss requires a consistent caloric deficit — not spot reduction or quick fixes. Dr. Joseph Wang uses this knowledge to design evidence-based weight management plans that target metabolic pathways rather than unsustainable extremes.
Sources
Reviewed against standard medical references.
Medically reviewed by
Family Physician & Registered Acupuncturist, Accord Medical Clinic. MBBS (NUS), Graduate Diploma in Family Medicine (NUS), Graduate Diploma in Acupuncture (Singapore College of TCM).
Last reviewed: August 2026
This page is general health education, not medical advice. Whether any treatment is appropriate for you is a decision made in consultation after assessment.